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Imine reductase (IRED)
Nipa Imine reductase
ES-IRED: Kilasi ti awọn enzymu ti o mu ki idinku C=N mnu si CN mnu.O jẹ ti enzymu redox, pẹlu coenzyme NADPH fun gbigbe hydrogen.Gẹgẹbi ayanfẹ chiral ti awọn ọja, wọn le pin si R-IRED ati S-IRED.Syncozymes ni idagbasoke 15 imine reductases (numbIRED ES-IRED-101-ES-IRED-115), eyiti o le ṣee lo ni lilo pupọ ni yiyan yiyan ati idinku stereoselective ti imines lati ṣeto awọn amines chiral.
Iru ifaseyin katalitiki:
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Nitrile reductase (NRED)
Nipa Nitrile reductase
Iru 3 wa ti ọja enzymu NRED (Nọmba bi ES-NRED101 ~ ES-NRED103) ti dagbasoke nipasẹ SyncoZymes.NRED le ṣe itọsi idinku ti ẹgbẹ nitrile si amine.Ninu ilana ti catalysis, NADPH ni a nilo bi olupona hydrogen.
Nitrile reductasecatalytic lenu iru
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Phenylalanine dehydrogenase (PDH)
Nipa Phenylalanine dehydrogenase
ES-PDH: Kilasi ti oxidoreductase.Idahun rere le ṣe itọsi deamination oxidative ti L phenylalanine iyọ ni iwaju NAD lati ṣe iyọ phenylpyruvate, ati ifapaarọ le ṣe itọpọ iṣelọpọ ti iyọ amino acid ti o baamu lati iyọ phenylpyruvate.Syncozymes ni idagbasoke awọn ohun kan 8 ti phenylalanine dehydrogenase (awọn nọmba ES-PDH-101 ~ ES-PDH-108).ES-PDH le ṣee lo lati ṣeto iyọ phenylalanine tabi iyo amino acid ti o baamu lati iyọ phenylpyruvic acid tabi awọn itọsẹ.
Iru ifaseyin katalitiki:
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Leucine Dehydrogenase (LeuDH)
Nipa Leucine dehydrogenase
Iru 1 wa ti ọja enzymu LeuDH (Nọmba bi ES-LeuDH-101) ti dagbasoke nipasẹ SyncoZymes.LeuDH le ṣe itọsi amoniation idinku ti 4-methylbutanoic acid (iyọ) si L-leucine tabi ifoyina ti leucine si 4-methylbutanoic acid.ES-LeuDH tun le mu ifasilẹ idinku ti α-keto acids pẹlu eto ti o jọra lati mura awọn itọsẹ amino acid ti o baamu.Ninu ilana ti catalysis, NADH jẹ pataki bi gbigbe hydrogen.
Leucine dehydrogenasecatalytic lenu iru
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Imeeli:lchen@syncozymes.com
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Threonine deaminase (TDA)
Nipa Threonine deaminase
ES-TDA (Threonine deaminase): amuaradagba fosifeti pyridoxal kan ti o ṣe itusilẹ deamination ti threonine lati ṣe agbejade 2-ketobutyric acid ati amonia.Pyridoxal 5-fosifeti jẹ pataki bi coenzyme ninu eto katalitiki.Iru 1 nikan wa ti ọja enzymu TDA (Nọmba bi ES-TDA) ti a dagbasoke nipasẹ SyncoZymes, eyiti o le ṣee lo lati mura 2-ketobutyric acid tabi awọn itọsẹ rẹ lati threonine.
Iru ifaseyin katalitiki:
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Amine Dehydrogenase (AmDH)
Nipa Amine Dehydrogenase
ES-AmDH (Amine Dehydrogenase): enzymu kan ti o le mu amoniation ti ẹgbẹ carbonyl dinku ati dinku si ẹgbẹ amino.O jẹ enzymu ti o gbẹkẹle coenzyme NADH, ati NADH n ṣiṣẹ bi atagba hydrogen.Awọn oriṣi mẹrin ti awọn ọja enzymu AmDH wa (Nọmba bi ES-AmDH101～ES-AmDH104) ti a dagbasoke nipasẹ SyncoZymes, eyiti o le ṣee lo ni yiyan isọdọtun tabi stereoselective reductive amination ti aldehydes ati awọn ketones.
Iru ifaseyin katalitiki:
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Nucloside phosphoryalse (NP)
Nipa nucleoside phosphoryalse
Awọn iru mẹta ti awọn ọja enzymu NP wa (Nọmba bi ES-NP-101 ~ ES-NP-103) ti a dagbasoke nipasẹ SyncoZymes.ES-NP-101 jẹ purine nucleoside phosphorylase, ES-NP-102 ati ES-NP-103 jẹ pyrimidine nucleoside phosphorylase.Nucleosidephosphorylase le decompose awọn nucleosides sinu awọn ipilẹ ati pentose fosifeti.Nucleoside phosphorylase ni a le pin si purine nucleoside phosphorylase ati pyrimidine nucleoside phosphorylase ni ibamu si ayanfẹ ti awọn ipilẹ nucleoside.Purine nucleoside phosphorylase le ṣe metabolize adenosine si adenine, inosine si hypoxanthine, guanosine si guanine, ati gbejade fosifeti ribose ni akoko kanna.Pyrimidine nucleoside phosphorylase le ṣe metabolize uridine si uracil ati gbejade fosifeti ribose.
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Imeeli:lchen@syncozymes.com
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Hydroaminase (HAM)
Nipa Hydroaminase
Awọn oriṣi 2 ti ọja henensiamu HAM (Nọmba bi ES-HAM-101 ~ ES-HAM-102) ni idagbasoke nipasẹ SyncoZymes.HAM le mu amoniation ti enoic acid tabi awọn itọsẹ rẹ lati gbe awọn amino acids chiral jade.HAM le ṣee lo lati ṣepọ awọn amino acids chiral (tabi amines chiral) lati awọn enoic acids (tabi alkenes).Oluranlọwọ Amonia, gẹgẹbi omi amonia tabi iyọ ammonium, jẹ pataki.
Hydroaminase katalitiki lenu iru
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CALB aibikita
CALB
Recombinant Lipase B lati Candida antarctica (CALB) jẹ iṣelọpọ nipasẹ bakteria submerged pẹlu pichia pastoris ti a ṣe atunṣe nipa jiini.
CALB le ṣee lo ni ipele omi tabi Organic fase catalytic esterification, esterolysis, transesterification, oruka šiši polyester kolaginni, aminolysis, hydrolysis ti amides, acylation ti amines ati afikun lenu.
CALB jẹ pẹlu yiyan chiral giga ati yiyan ipo, nitorinaa o le ṣee lo ni lilo pupọ ni sisẹ epo, ounjẹ, oogun, ohun ikunra ati awọn ile-iṣẹ kemikali miiran.
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NADH oxidase (NOX)
Nipa NADH oxidase
ES-NOX (NADH oxidase): NOX ṣe itọsi oxidation ti NADH si NAD +, ati pe o jẹ ti oxidoreductase.Ninu ilana ti ifoyina, O2 jẹ pataki bi oxidant, ati dinku si H2O tabi H2O2.Awọn iru 4 wa ti awọn ọja enzymu NOX (ES-NOX-101 ~ ES-NOX-104) ti o dagbasoke nipasẹ ile-iṣẹ wa, eyiti o le ṣee lo fun isọdọtun oxidation ti coenzyme NAD +.
Iru ifaseyin katalitiki:
or
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Phenylalanine amonia lyase (PAL)
Nipa Phenylalanine amonia lyase
ES-PAL: Kilasi ti awọn ensaemusi ti o jẹ ki deamination taara ti L-phenylalanine si trans-cinnamic acid.Syncozymes ni idagbasoke awọn ohun 10 ti phenylalanine amonia lyase (ti a ṣe nọmba ES-PAL-101~ES-PAL-110), eyiti o le ṣee lo ni deamination tabi ifaseyin ti phenylalanine ati awọn itọsẹ rẹ.
Iru ifaseyin katalitiki:
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Catalase (CAT)
Nipa Catalase
ES-CAT (Catalase): ṣe itọsi jijẹjijẹ ti H2O2 sinu atẹgun ati omi.O wa ni akọkọ ni mitochondria, reticulum endoplasmic, ẹdọ ẹranko ati awọn sẹẹli ẹjẹ pupa, ni pataki ninu ẹdọ ni ifọkansi giga, pese iṣẹ aabo antioxidant fun ara.Ni biocatalysis, o jẹ lilo ni akọkọ lati yọkuro ifaseyin nipasẹ ọja-ọja hydrogen peroxide ati dinku idinamọ ati imuṣiṣẹ ti henensiamu nipasẹ hydrogen peroxide.Iru 1 nikan wa ti awọn ọja enzymu CAT ti o dagbasoke nipasẹ SyncoZymes (Nọmba bi ES-CAT).
Iru ifaseyin katalitiki:
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