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Oxynitrilases (HNL)
Nipa oxynitrilases
ES-HNLs: Enzymu kilasi kan ti o mu ki afikun HCN si aldehydes (ketones) lati gba awọn ọti cyanide iru R tabi S, eyiti o le yipada ni irọrun si ọpọlọpọ awọn oogun tabi awọn agbedemeji oogun nipasẹ ọna kemikali.
Awọn iru 29 ti awọn ọja oxynitrilase wa (Nọmba bi ES-HNL-101～ES-HNL-129) ti a dagbasoke nipasẹ SyncoZymes.SZ-HNL jẹ ohun elo ti o wulo fun iṣelọpọ regio- ati sitẹrio-aṣayan ti (R) -cyanohydrins tabi (S) -cyanohydrins lati oriṣiriṣi aromatic, aliphatic ati heterocyclic aldehydes tabi paapaa awọn ketones.
Irisi ifasilẹ katalitiki:
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Nitro reductase (NTR)
Nipa nitro reductase
ES-NTRs: Ṣe awọn flavoenzymes ti o jẹ ki idinku NAD (P) H ti o gbẹkẹle idinku ti awọn ẹgbẹ nitro lori nitroaromatic ati awọn agbo ogun nitroheterocyclic si hydroxylamino ati/tabi awọn itọsẹ amino.Wọn ti wa ni lilo pupọ ni iṣelọpọ Organic ti aromatic hydroxylamine ati amine aromatic, itọju tumo, iṣawari ti ibi ati ibajẹ ti awọn idoti ayika.Awọn iru 12 ti Nitro reductase (NTR) awọn ọja (Nọmba bi ES-NTR-101~ES-NTR-112) ti dagbasoke nipasẹ SyncoZymes.
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Aldolase (DERA)
ES-DERAs: Le ṣe imunadoko ni imunadoko ni afikun stereoselective ti awọn ketones olugbeowosile si aldehydes olugba.Pẹlupẹlu, iṣesi naa le ṣee ṣe ni ojutu olomi ti pH didoju laisi awọn igbese aabo pataki.Wọn jẹ ti kilasi I aldolase, eyiti o ṣe ipilẹ Shiff ni ilana kataliti.Sobusitireti ti wa ni isomọ pẹlu ẹgbẹ amino ti aaye ti nṣiṣe lọwọ lati pilẹṣẹ fifọ ati didasilẹ mnu.Iyatọ laarin awọn DERA ati awọn aldolases miiran ni pe awọn sobusitireti ti wọn ṣe itọsi jẹ aldehydes ati pe o le gba ifunmọ aldehydes lemọlemọ.
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Cytochrome P450 monooxygenase (CYP)
Nipa CYP
ES-CYPs: Kilasi ti awọn ensaemusi redox pẹlu mercaptan-heme gẹgẹbi ile-iṣẹ ti nṣiṣe lọwọ lati ṣe itọsi gbigbe atẹgun.Wọn jẹ oxygenases ebute ati nilo heme lati mu atẹgun ṣiṣẹ.
Cytochrome P450 monooxygenase ṣe itọsi ifoyina, epoxideation ati hydroxylation ti alkyl, hydroxylation ati oxidation ti amonia, ifoyina ti sulfur, dealkylation (atẹgun, sulfur, amonia), dehydrogenation oxidative, deamination ati dehalogenation.
Awọn oriṣi 8 ti awọn ọja cytochrome P450 monooxygenase (Nọmba bi ES-CYP-101～ES-CYP-108) ni idagbasoke nipasẹ SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
Imeeli:lchen@syncozymes.com
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Ọtí oxidase (AOX)
Nipa oti oxidase
ES-AOXs: Awọn enzymu wọnyi ni anfani lati ṣe itọsi ifoyina ti awọn ọti-ọra ti o sanra tabi aryl-alcohols lati ṣe awọn aldehydes.Wọn lo atẹgun molikula ṣugbọn ko nilo cofactor ti a ṣafikun ita, ati hydrogen peroxide ti a ṣe.
Awọn iru awọn ọja oxidases ọti-lile 6 wa (Nọmba bi ES-AOX-101 ~ ES-AOX-106) ti a dagbasoke nipasẹ SyncoZymes.ES-AOX101 ati ES-AOX102 fẹ awọn sobusitireti oti aliphatic, ES-AOX103~ ES-AOX105 fẹ awọn sobusitireti oti aromatic, ati ES-AOX106 jẹ oxidase cholesterol.SZ-AOX jẹ ohun elo ti o wulo lati ṣe itọsi ifoyina ti awọn ọti-ọra ti o sanra tabi aryl-alcohols lati ṣe awọn aldehydes.
Irisi ifasilẹ katalitiki:
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D-Amino acid dehydrogenase (D-AADH)
Nipa D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): enzymu kan ti o le dinku 2-keto acid sinu D-amino acid ti o baamu.Idahun naa nilo NADP (H) ati oluranlọwọ amonia inorganic (gẹgẹbi amonia tabi ammonium ion).Awọn iru 17 wa ti D-amino acid dehydrogenases (Nọmba bi ES-DAADH-101~ ES-DAADH-117) ni idagbasoke nipasẹ SyncoZymes.
Irisi ifasilẹ katalitiki:
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Esterase&Lipase (PLE&CALB)
Nipa Esterase&Lipase
ES-PLEs: Kilasi ti awọn hydrolases ti o jẹ ki dida ati fifọ awọn iwe adehun ester.Wọn le kopa ninu ọpọlọpọ awọn iru awọn aati biokemika, gẹgẹbi esterification, transesterification ati hydrolysis.Wọn ti wa ni lilo pupọ ni ọpọlọpọ awọn aaye bii ṣiṣe ounjẹ, ile-iṣẹ kemikali, biomedicine, oogun chiral ati itọju ayika.
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Epoxide hydrolase (EH)
Nipa epoxide hydrolase
EH jẹ ether hydrolase ti o ṣe itọsi hydrolysis stereoselective ti awọn epoxides racemic lati ṣe agbejade 1, 2-diol ati awọn epoxides ti nṣiṣe lọwọ optically, eyiti o le ṣee lo fun ipinnu chiral ti epoxides tabi igbaradi ti awọn diol chiral.Wọn ti wa ni lilo pupọ ni oogun ati awọn aaye miiran.Awọn iru mẹta ti epoxide hydrolases awọn ọja (Nọmba bi ES-EH-101～ES-EH-103) ti dagbasoke nipasẹ SyncoZymes.ES-EH jẹ ohun elo ti o wulo lati ṣaṣepọ iṣelọpọ ti awọn ọti oyinbo chiral nipasẹ stereoselective hydrolysis ti aliphatic ati awọn epoxides aromatic.
Irisi ifasilẹ katalitiki:
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Ṣe agbekalẹ dehydrogenase (FDH)
Nipa Formate dehydrogenase
ES-FDH (Formate dehydrogenase): FDH ṣe itọsi gbigbẹ ti ammonium formate lati ṣe agbejade carbon dioxide ati amonia, ati dinku NAD si NADH pẹlu NAD bi olugba elekitironi.FDH nigbagbogbo lo fun isọdọtun ti coenzyme NADH.Awọn oriṣi mẹrin ti awọn ọja enzymu FDH wa (ES-FDH-101~ES-FDH-104) ti a dagbasoke nipasẹ SyncoZymes, laarin eyiti ES-FDH102 ni iṣẹ ṣiṣe ti o ga julọ ati pe o jẹ FDH akọkọ ti a ṣeduro.
Irisi ifasilẹ katalitiki:
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Glucose dehydrogenase (GDH)
Nipa glukosi dehydrogenase
ES-GDH (Glucose dehydrogenase): GDH ṣe itọsi dehydrogenation ti glukosi lati ṣe agbejade gluconic acid (lactone), ati dinku NAD (P) + si NAD (P) H, pẹlu NAD (P) + bi olugba itanna.GDH nigbagbogbo lo fun isọdọtun ti coenzyme NAD (P) H ni awọn aaye biocatalysis pẹlu enzymu akọkọ miiran.Awọn iru 10 ti awọn ọja enzymu GDH wa (ES-GDH-101~ES-GDH-110) ti a dagbasoke nipasẹ SyncoZymes, laarin eyiti ES-GDH110 ni iṣẹ ṣiṣe ti o ga julọ ati pe o jẹ GDH akọkọ ti a ṣeduro.
Irisi ifasilẹ katalitiki:
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Monoamine oxidase (MAO)
Nipa Monoamine oxidase
ES-MAO (Monoamine oxidase): MAO ṣe itọsi deamination oxidative ti awọn monoamines lati ṣe agbejade hydrogen peroxide, amonia ati awọn aldehydes ti o baamu.Ninu ilana katalitiki, atẹgun jẹ pataki bi oxidant.Awọn iru 6 ti awọn ọja enzymu MAO wa (Nọmba bi ES-MAO-101～ES-MAO-106) ti a dagbasoke nipasẹ SyncoZymes, eyiti o le ṣee lo ninu deamination oxidative ti awọn agbo ogun monoamine.
Irisi ifasilẹ katalitiki:
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Lactate Dehydrogenase (LDH)
Nipa Lactate dehydrogenase
Iru 1 ọja enzymu LDH wa (Nọmba bi ES-LDH) ti a dagbasoke nipasẹ SyncoZymes.LDH le ṣe itọsi idinku ti pyruvate si L-lactic acid, tabi idinku awọn acids α-keto miiran ti o jọra.Ninu ilana ti catalysis, NADH jẹ pataki bi gbigbe hydrogen.
Lactate dehydrogenasecatalytic lenu iru
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