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Ketoreductase (KRED)
Nipa Ketoreductase
Awọn enzymu: Ṣe awọn oludasọna ti ibi-ara macromolecular, pupọ julọ awọn enzymu jẹ awọn ọlọjẹ.
Ketoreductase: Tun npe ni “Carbonyl reductase”, jẹ awọn ensaemusi ti o ṣe itusilẹ ifaseyin redox iyipada laarin aldehydes / ketones ati awọn ọti-lile, ati nilo awọn coenzymes bi Atagba H gẹgẹbi NADH tabi NADPH.Awọn ẹka akọkọ mẹta wa ti KRED: Dehydrogenase kukuru kukuru / Reductases (SDRs), Dehydrogenases pq Alabọde / Reductases (MDRs), ati Aldo-KetoReductases (AKRs).Awọn iṣẹ katalitiki ti awọn mẹta jẹ iru, ṣugbọn eto ati awọn ohun-ini yatọ pupọ.
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Imeeli:lchen@syncozymes.com
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Transaminase (ATA)
Nipa transaminase
ATA lati SyncoZymes: Awọn iru 66 ti awọn ọja enzymu ATA wa (Nọmba bi ES-ATA-101~ES-ATA-166) ti a dagbasoke nipasẹ SyncoZymes.SZ-ATA jẹ ohun elo ti o wulo lati ṣe itusilẹ regio- ati iṣelọpọ stereoselective ti amines chiral, amino acids ati awọn itọsẹ wọn lati oriṣiriṣi aliphatic ati ketoacids aromatic, aldehydes, ketones ati ketoses.
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Imeeli:lchen@syncozymes.com
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Nitrilase (NIT)
Nipa Nitrilase
ES-NITs: Yipada ẹgbẹ cyanide taara si ẹgbẹ carboxyl, lati mura carboxylic acid, eyiti o lo pupọ ni oogun, aabo ayika, ile-iṣẹ kemikali, afikun ounjẹ, aṣọ, iṣelọpọ ogbin ati awọn aaye miiran.
Awọn iru 40 ti awọn ọja Nitrilase (NIT) wa (Nọmba bi ES-NIT-101~ES-NIT-140) ti a dagbasoke nipasẹ SyncoZymes.ES-NIT jẹ ohun elo ti o wulo lati mu iṣelọpọ ti chiral carboxylic acids nipasẹ regio- ati stereoselective hydrolysis ti ọpọlọpọ awọn aliphatic ati nitriles aromatic.Irisi ifasilẹ katalitiki:
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Nitrile hydratase (NHT)
Nipa ES-NHT
ES-NHTs: kilasi ti metalloenzyme, eyiti o yan awọn nitriles ni yiyan sinu amide akọkọ ti o baamu.Wọn ti wa ni o gbajumo ni lilo ko nikan fun awọn kolaginni ti amino acids, amides, carboxylic acids ati awọn itọsẹ wọn, sugbon o tun fun igbaradi ti chiral oloro.Awọn iru 24 nitrile hydratases ni idagbasoke nipasẹ SyncoZymes (Nọmba bi ES-NHT-101～ES-NHT-124).
Iru ifaseyin katalitiki:
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Amidase (AMD)
AMD lati SyncoZymes: Awọn iru 19 ti awọn ọja enzymu AMD wa (Nọmba bi ES-AMD-101~ES-AMD-119) ti dagbasoke nipasẹ SyncoZymes.SZ-AMD jẹ ohun elo ti o wulo lati ṣe itusilẹ regio- ati iṣelọpọ stereoselective ti chiral carboxylic acids ati awọn itọsẹ wọn lati oriṣiriṣi aliphatic ati awọn amides aromatic.
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Imeeli:lchen@syncozymes.com
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Ene reductase (ERED)
Nipa ene reductase
ES-EREDs: Jẹ ti ẹbi ti awọn enzymu ofeefee atijọ ti o yan C = C ni yiyan ni α, awọn agbo ogun β-unsaturated pẹlu awọn ẹgbẹ gbigba elekitironi.Wọn ti wa ni lilo pupọ ni ikẹkọ ti awọn itọsẹ amino acid, awọn nkan bioactive, awọn agbedemeji elegbogi, awọn turari ati awọn bulọọki chiral.
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Imeeli:lchen@syncozymes.com
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Oxynitrilases (HNL)
Nipa oxynitrilases
ES-HNLs: Enzymu kilasi kan ti o mu ki afikun HCN si aldehydes (ketones) lati gba iru awọn ọti cyanide R tabi S, eyiti o le yipada ni irọrun si ọpọlọpọ awọn oogun tabi awọn agbedemeji oogun nipasẹ ọna kemikali.
Awọn iru 29 ti awọn ọja oxynitrilase wa (Nọmba bi ES-HNL-101～ES-HNL-129) ti a dagbasoke nipasẹ SyncoZymes.SZ-HNL jẹ ohun elo ti o wulo fun iṣelọpọ regio- ati sitẹrio-aṣayan ti (R) -cyanohydrins tabi (S) -cyanohydrins lati oriṣiriṣi aromatic, aliphatic ati heterocyclic aldehydes tabi paapaa awọn ketones.
Iru ifaseyin katalitiki:
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Imeeli:lchen@syncozymes.com
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Nitro reductase (NTR)
Nipa nitro reductase
ES-NTRs: Ṣe awọn flavoenzymes ti o jẹ ki idinku NAD (P) H ti o gbẹkẹle idinku ti awọn ẹgbẹ nitro lori nitroaromatic ati awọn agbo ogun nitroheterocyclic si hydroxylamino ati/tabi awọn itọsẹ amino.Wọn ti wa ni lilo pupọ ni iṣelọpọ Organic ti aromatic hydroxylamine ati amine aromatic, itọju tumo, iṣawari ti ibi ati ibajẹ ti awọn idoti ayika.Awọn iru 12 ti Nitro reductase (NTR) awọn ọja (Nọmba bi ES-NTR-101~ES-NTR-112) ti dagbasoke nipasẹ SyncoZymes.
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Imeeli:lchen@syncozymes.com
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Aldolase (DERA)
ES-DERAs: Le ṣe imunadoko ni imunadoko ni afikun stereoselective ti awọn ketones olugbeowosile si aldehydes olugba.Pẹlupẹlu, iṣesi naa le ṣee ṣe ni ojutu olomi ti pH didoju laisi awọn igbese aabo pataki.Wọn jẹ ti kilasi I aldolase, eyiti o ṣe ipilẹ Shiff ni ilana kataliti.Sobusitireti ti wa ni isomọ pẹlu ẹgbẹ amino ti aaye ti nṣiṣe lọwọ lati pilẹṣẹ fifọ ati didasilẹ mnu.Iyatọ laarin awọn DERA ati awọn aldolases miiran ni pe awọn sobusitireti ti wọn ṣe itọsi jẹ aldehydes ati pe o le gba ifunmọ aldehydes lemọlemọ.
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Imeeli:lchen@syncozymes.com
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Cytochrome P450 monooxygenase (CYP)
Nipa CYP
ES-CYPs: Kilasi ti awọn ensaemusi redox pẹlu mercaptan-heme gẹgẹbi ile-iṣẹ ti nṣiṣe lọwọ lati ṣe itọsi gbigbe atẹgun.Wọn jẹ oxygenases ebute ati nilo heme lati mu atẹgun ṣiṣẹ.
Cytochrome P450 monooxygenase ṣe itọsi ifoyina, epoxideation ati hydroxylation ti alkyl, hydroxylation ati oxidation ti amonia, ifoyina ti sulfur, dealkylation (atẹgun, sulfur, amonia), dehydrogenation oxidative, deamination ati dehalogenation.
Awọn oriṣi 8 ti awọn ọja cytochrome P450 monooxygenase (Nọmba bi ES-CYP-101～ES-CYP-108) ni idagbasoke nipasẹ SyncoZymes.Mobile/Wechat/WhatsApp: +86-13681683526
Imeeli:lchen@syncozymes.com
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Ọtí oxidase (AOX)
Nipa oti oxidase
ES-AOXs: Awọn enzymu wọnyi ni anfani lati ṣe itọsi ifoyina ti awọn ọti-ọra tabi awọn ọti aryl lati dagba awọn aldehydes.Wọn lo atẹgun molikula ṣugbọn ko nilo cofactor ti a ṣafikun ita, ati hydrogen peroxide ti a ṣe.
Awọn iru awọn ọja oxidases ọti-lile 6 wa (Nọmba bi ES-AOX-101 ~ ES-AOX-106) ti a dagbasoke nipasẹ SyncoZymes.ES-AOX101 ati ES-AOX102 fẹ awọn sobusitireti oti aliphatic, ES-AOX103~ ES-AOX105 fẹ awọn sobusitireti oti aromatic, ati ES-AOX106 jẹ oxidase cholesterol.SZ-AOX jẹ ohun elo ti o wulo lati ṣe itọsi ifoyina ti awọn ọti-ọra ti o sanra tabi aryl-alcohols lati ṣe awọn aldehydes.
Irisi ifasilẹ katalitiki:
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D-Amino acid dehydrogenase (D-AADH)
Nipa D-Amino acid dehydrogenase
ES-D-AADH (D-Amino acid dehydrogenase): enzymu kan ti o le dinku 2-keto acid sinu D-amino acid ti o baamu.Idahun naa nilo NADP (H) ati oluranlọwọ amonia inorganic (gẹgẹbi amonia tabi ammonium ion).Awọn iru 17 wa ti D-amino acid dehydrogenases (Nọmba bi ES-DAADH-101~ ES-DAADH-117) ni idagbasoke nipasẹ SyncoZymes.
Irisi ifasilẹ katalitiki:
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