Clenbuterol, jẹ agonist β2-adrenergic (β2-adrenergic agonist), ti o jọra si ephedrine (Ephedrine), ni a maa n lo ni ile-iwosan nigbagbogbo lati ṣe itọju aarun obstructive ẹdọforo (COPD), O tun lo bi bronchodilator lati yọkuro awọn exacerbations nla ti ikọ-fèé.Ni ibẹrẹ ọdun 1980, ile-iṣẹ Amẹrika Cyanamid lairotẹlẹ ṣe awari pe o ni awọn ipa ti o han gbangba ti igbega idagbasoke, imudarasi oṣuwọn ẹran ti o tẹẹrẹ ati idinku ọra, nitorinaa o lo bi clenbuterol ni igbẹ ẹran.Sibẹsibẹ, nitori awọn ipa ẹgbẹ rẹ, European Community ti gbesele lilo clenbuterol bi afikun ifunni lati Oṣu Kini Ọjọ 1, Ọdun 1988. FDA ti fi ofin de ni ọdun 1991. Ni ọdun 1997, Ile-iṣẹ ti Agriculture ti Orilẹ-ede Eniyan China ti ni idinamọ muna. lilo awọn homonu beta-adrenergic ni ifunni ati iṣelọpọ ẹran-ọsin, ati Clenbuterol hydrochloride ni ipo akọkọ.
Sibẹsibẹ, Clenbuterol racemic ti han laipẹ lati dinku eewu ti arun Pakinsini.Lati jẹrisi eyi ti (tabi mejeeji) isomers gbejade ipa yii, Clenbuterol enantiomer funfun nilo lati ṣe iwadi lọtọ.
Ninu àpilẹkọ kan laipe, ẹgbẹ iwadi ti Elisabeth Egholm Jacobsen ti Ẹka ti Kemistri, Ile-ẹkọ giga ti Imọ-ẹrọ ati Imọ-ẹrọ ti Norwegian, ni ifowosowopo pẹlu Dr. Zhu Wei ti Shangke Bio, ṣe iṣeduro iṣelọpọ ti ketoreductase KRED ati cofactor nicotinamide adenine dinucleoside phosphate (NADPH). ).(R) -1- (4-Amino-3,5-dichlorophenyl) -2-bromoethan-1-ol, ee> 93%;ati (S) -N- (2 ti ṣajọpọ nipasẹ eto kanna, 6-Dichloro-4- (1-hydroxyethyl) phenyl) acetamide, ee> 98%.Mejeji ti awọn agbedemeji ti o wa loke jẹ awọn ipilẹṣẹ ti o pọju ti awọn isomers clenbuterol.Ketoreductase ES-KRED-228 ti a lo ninu iwadi yii jẹ lati Shangke Biopharmaceutical (Shanghai) Co., Ltd. abajade iwadi "Chemoenzymatic Synthesis of Synthons as Precursors for Enantiopure Clenbuterol and Other -2-Agonists" ni a tẹjade ni "Catalysts" lori Oṣu kọkanla ọjọ 4, ọdun 2018.
Akoko ifiweranṣẹ: Oṣu Kẹjọ-26-2022